Friday, July 27, 2012

COW Week 4 Answer

This patient should have been started on argatroban 2 days ago when HIT was suspected and should stay in the hospital for minimum 2 weeks on an argatroban drip. Fonadaprinux can be used off-label for outpatient management but this is not FDA approved. Coumadin is not appropriate as HIT is a very hypercoagulable state requiring a “true” anticoagulant. Coumadin does not inhibit activated clotting factors and has also been associated with a purpura fulminans kind of syndrome in this setting. Up to 50% of patients with HIT develop thrombosis.

Words of Wisdom from Dr. Rosove:
This patient has heparin induced thrombocytopenia (HIT). HIT develops anywhere from day 4 to 14 of de novo therapy. It takes that long for IgG antibodies to the heparin-platelet factor 4 complex to develop. Thrombocytopenia can occur earlier than day 4, even immediately, upon exposure to unfractionated heparin (UFH) if there has been a recent exposure to any glycosaminoglycan anticoagulant, GAG, (UFH, LMWH, or fondaparinux) such that antibodies are already present. This patient was exposed to heparin recently which is why her platelets dropped so quickly.

HIT patients must be anticoagulated for a minimum of two weeks (3 months per Board Review), even if there is full recovery of the platelet count, no evident thrombosis, and no need for longer-term anticoagulation. By two weeks, nearly all of the acute risk has passed. If there is evidence of thrombosis then one must be anti-coagulated for 3-6months. The only FDA-approved anticoagulants for HIT are argatroban, bivalirudin, and lepirudin (the first two are on our formulary), but these are IV infusions, thus requiring inpatient care. Therefore fondaparinux SQ is often given off-label to allow outpatient management. Fondaprinux may perpetuate antibody formation but is virtually incapable of causing HIT. Rivaroxaban or dabigatran could also serve in the same capacity since they are not GAGs, but neither have been tested and thus should not be used at this time.

HIT is a preventable problem. By far it occurs more frequently with UFH than LMWH, and HIT due to fondaparinux is practically reportable. Therefore, whenever there is a reasonable choice of which anticoagulant to use, UFH is best avoided altogether. In the case of unstable angina and percutaneous coronary interventions, there are legitimate alternatives to UFH.

A positive HAPA, no matter how strongly positive, only permits a diagnosis of HIT, it does not make a diagnosis since the majority of patients who are antibody positive do not have HIT. However, the negative predictive value of HAPA is nearly perfect.

Friday, July 20, 2012

COW Week 3 Answer

Answer: 1 and 3

ALLHAT was a double blind RCT evaluating adults with HTN and at least one cardiac risk factor (prior MI, CVA, LVH, DM, Tob, low HDL, known atherosclerosis) and randomized them to 3 groups: Amlodipine vs Chlorthalidone vs Lisinopril. After 5 years, 68% of patients in the Chlorthalidone group achieved the blood pressure goal (less than140/90) vs 66% in the Amlodipine group and 61% in the Lisinopril group. There was no difference in all cause mortality or fatal coronary heart disease and nonfatal MIs. However, the Chlorthalidone group did have a significant decrease in Heart failure and stroke when compared to Lisinopril. Based on ALLHAT, a thiazide diuretic, chlorthalidone, is at least as effective if not better than several other medications as first line therapy in high risk patients with hypertension and it is definitely cheaper. For this reason, the JNC 7 recommends thiazides as first line agents for hypertension in most patients.

In this vignette, the patient has diabetic nephropathy due to his proteinuria. In such patients, JNC 7 recommends an ACE/ARB as first line treatment rather than a thiazide. However, the patient has stage II hypertension for which JNC recommends 2 medications as initial therapy. Thus, this patient should be started on both a Thiazide and ACE/ARB.

Lastly, the ACCOMPLISH trial compared HCTZ and Benazepril vs Amlodipine and Benazepril in patients with HTN and high cardiovascular risk and showed Amlodipine to be superior by decreasing cardiovascular events. Some experts believe this is due to HCTZ being a less potent Thiazide than Chlorthalidone. Stay tuned to the upcoming JNC 8 to see if the recommendations change!! Click on the link below to see the articles.

 ALLHAT
ACCOMPLISH

Friday, July 13, 2012

COW Week 2 Answer

The AIM-HIGH Study (N Engl J Med 2011; 365:2255-2267) looked at patients with established cardiovascular disease already on appropriate statin therapy who had low LDL and low HDL. They were randomized to statin alone or statin plus niacin. There was no incremental clinical benefit from the addition of niacin to statin therapy during a 36-month follow-up period, despite significant improvements in HDL cholesterol and triglyceride levels.

The ACCORD Trial (N Engl J Med 2010; 362:1563-1574) looked at combination lipid therapy in type 2 diabetes and found no difference in cardiovascular outcomes between statin alone and statin plus fenofibrate. However, a subgroup analysis of patients with low HDL and triglycerides above 200 did show improved outcomes. Based on this subgroup, a new clinical trial is currently underway to study whether addition of fibrates to patients on optimal statin therapy (ie: LDL less than 70) with low HDL and high triglycerides reduces cardiovascular mortality. 

So niacin is out, but the the utility of fibrates is yet to be determined.

Remember: just because the numbers look good doesn't mean it has any clinical significance!


Wednesday, July 11, 2012

Choosing Wisely

Choosing Wisely:  ABIM asked professional societies how best to eliminate high-cost/low value care.  Consumer Reports got on board and the result was this.  See the link to the lists from each society with the rationale for each.   Below is the full list.

Choosing Wisely


1. Don’t perform unproven diagnostic tests, such as immunoglobulin G (IgG) testing or an indiscriminate battery of immunoglobulin E (IgE) tests, in the evaluation of allergy.

2. Don’t order sinus computed tomography (CT) or indiscriminately prescribe antibiotics for uncomplicated acute rhinosinusitis.

3. Don’t routinely do diagnostic testing in patients with chronic urticaria.

4. Don’t recommend replacement immunoglobulin therapy for recurrent infections unless impaired antibody responses to vaccinesare demonstrated.

5. Don’t diagnose or manage asthma without spirometry.

6. Don’t do imaging for low back pain within the first six weeks, unless red flags are present.

7. Don’t routinely prescribe antibiotics for acute mild-to-moderate sinusitis unless symptoms last for seven or more days, or symptoms worsen after initial clinical improvement.

8. Don’t use dual-energy x-ray absorptiometry (DEXA) screening for osteoporosis in women younger than 65 or men younger than 70 with no risk factors.

9. Don’t order annual electrocardiograms (EKGs) or any other cardiac screening for low-risk patients without symptoms.

10. Don’t perform Pap smears on women younger than 21 or who have had a hysterectomy for non-cancer disease.

11. Don’t perform stress cardiac imaging or advanced non-invasive imaging in the initial evaluation of patients without cardiac symptoms unless high-risk markers are present.

12. Don’t perform annual stress cardiac imaging or advanced non-invasive imaging as part of routine follow-up in asymptomatic patients.

13. Don’t perform stress cardiac imaging or advanced non-invasive imaging as a pre-operative assessment in patients scheduled to undergo low-risk non-cardiac surgery.

14. Don’t perform echocardiography as routine follow-up for mild, asymptomatic native valve disease in adult patients with no change in signs or symptoms.

15. Don’t perform stenting of non-culprit lesions during percutaneous coronary intervention (PCI) for uncomplicated hemodynamically stable ST-segment elevation myocardial infarction (STEMI).

16. Don’t obtain screening exercise electrocardiogram testing in individuals who are asymptomatic and at low risk for coronary heart disease.

17. Don’t obtain imaging studies in patients with non-specific low back pain.

18. In the evaluation of simple syncope and a normal neurological examination, don’t obtain brain imaging studies (CT or MRI).

19. In patients with low pretest probability of venous thromboembo­lism (VTE), obtain a high-sensitive D-dimer measurement as the initial diagnostic test; don’t obtain imaging studies as the initial diagnostic test.

20. Don’t obtain preoperative chest radiography in the absence of a clinical suspicion for intrathoracic pathology.

21. Don’t do imaging for uncomplicated headache.

22. Don’t image for suspected pulmonary embolism (PE) without moderate or high pre-test probability.

23. Avoid admission or preoperative chest x-rays for ambulatory patients with unremarkable history and physical exam.

24. Don’t do computed tomography (CT) for the evaluation of suspected appendicitis in children until after ultrasound has been considered as an option.

25. Don’t recommend follow-up imaging for clinically inconsequential adnexal cysts.

26. For pharmacological treatment of patients with gastroesophageal reflux disease (GERD), long-term acid suppression therapy (proton pump inhibitors or histamine2 receptor antagonists) should be titrated to the lowest effective dose needed to achieve therapeutic goals.

27. Do not repeat colorectal cancer screening (by any method) for 10 years after a high-quality colonoscopy is negative in average-risk individuals.

28. Do not repeat colonoscopy for at least five years for patients who have one or two small (< 1 cm) adenomatous polyps, without high-grade dysplasia, completely removed via a high-quality colonoscopy.

29. For a patient who is diagnosed with Barrett’s esophagus, who has undergone a second endoscopy that confirms the absence of dysplasia on biopsy, a follow-up surveillance examination should not be performed in less than three years as per published guidelines.

30. For a patient with functional abdominal pain syndrome (as per ROME III criteria) computed tomography (CT) scans should not be repeated unless there is a major change in clinical findings or symptoms.

31. Don’t use cancer-directed therapy for solid tumor patients with the following characteristics: low performance status (3 or 4), no benefit from prior evidence-based interventions, not eligible for a clinical trial, and no strong evidence supporting the clinical value of further anti-cancer treatment.

32. Don’t perform PET, CT, and radionuclide bone scans in the staging of early prostate cancer at low risk for metastasis.

33. Don’t perform PET, CT, and radionuclide bone scans in the staging of early breast cancer at low risk for metastasis.

34. Don’t perform surveillance testing (biomarkers) or imaging (PET, CT, and radionuclide bone scans) for asymptomatic individuals who have been treated for breast cancer with curative intent.

35. Don’t use white cell stimulating factors for primary prevention of febrile neutropenia for patients with less than 20 percent risk for this complication.

36. Don’t perform routine cancer screening for dialysis patients with limited life expectancies without signs or symptoms.

37. Don’t administer erythropoiesis-stimulating agents (ESAs) to chronic kidney disease (CKD) patients with hemoglobin levels greater than or equal to 10 g/dL without symptoms of anemia.

38. Avoid nonsteroidal anti-inflammatory drugs (NSAIDS) in individuals with hypertension or heart failure or CKD of all causes, including diabetes.

39. Don’t place peripherally inserted central catheters (PICC) in stage III–V CKD patients without consulting nephrology.

40. Don’t initiate chronic dialysis without ensuring a shared decision-making process between patients, their families, and their physicians.

41. Don’t perform stress cardiac imaging or coronary angiography in patients without cardiac symptoms unless high-risk markersare present.

42. Don’t perform cardiac imaging for patients who are at low risk.

43. Don’t perform radionuclide imaging as part of routine follow-up in asymptomatic patients.

44. Don’t perform cardiac imaging as a pre-operative assessment in patients scheduled to undergo low- or intermediate-risknon-cardiac surgery.

45. Use methods to reduce radiation exposure in cardiac imaging, whenever possible, including not performing such tests when limited benefits are likely.

Friday, July 6, 2012

COW Week 1 Answer

The new guidelines recommend starting HAART therapy on asymptomatic HIV patients at any CD4 count!! This is a level BIII recommendation (meaning moderate recommendation based on expert opinion). This reflects the increasing evidence that HIV viremia leads to inflammation and non-AIDS related morbidity as well as decreasing transmission.

Panel’s Recommendations

1) Antiretroviral therapy (ART) is recommended for all HIV-infected individuals. The strength of this recommendation varies on the basis of pretreatment CD4 cell count:
        CD4 count <350 cells/mm3 (AI)
        CD4 count 350 to 500 cells/mm3 (AII)
        CD4 count >500 cells/mm3 (BIII)

2) Regardless of CD4 count, initiation of ART is strongly recommended for individuals with the following conditions:
        Pregnancy (AI) (see perinatal guidelines for more detailed discussion)
        History of an AIDS-defining illness (AI)
        HIV-associated nephropathy (HIVAN) (AII)
        HIV/hepatitis B virus (HBV) coinfection (AII)

3) Effective ART also has been shown to prevent transmission of HIV from an infected individual to a sexual partner; therefore, ART should be offered to patients who are at risk of transmitting HIV to sexual partners (AI [heterosexuals] or AIII [other transmission risk groups]).

4) Patients starting ART should be willing and able to commit to treatment and should understand the benefits and risks of therapy and the importance of adherence (AIII). Patients may choose to postpone therapy, and providers, on a case-by-case basis, may elect to defer therapy on the basis of clinical and/or psychosocial factors.

Rating of Recommendations:  A = Strong; B = Moderate; C = Optional
Rating of Evidence:  I = data from randomized controlled trials; II = data from well-designed nonrandomized trials or observational cohort studies with long-term clinical outcomes; III = expert opinion

For more information, click on the link below:
DHHS HIV Guidelines

Thursday, June 28, 2012

Clinical Question of the Week

We're starting a Clinical Question of the Week, AKA COW. It will be posted early in the week with answers posted Friday afternoon. Please scroll to the bottom of the mobile homepage to see the question. Stacy Weinstein says "learning is the new pashmina!"

Wednesday, November 16, 2011

Housestaff Awards - Congrats!

Shipra Hingorany was awarded 2nd place in the DOM Research Day Poster Competition in the Clinical/Health Services Research, Trainee category - Management of Diabetes with Metformin in Patients with Chronic Heart Failure$2000 honorarium!


Rena Shah won 3rd place in the poster competition at the ACP Regional Conference!


UCLA Jeopardy Team (Danny Kahn, Holly Thomas, Alex Viehman) won first place in the IM program regional competition and will compete in the National competition in New Orleans (paid trip by ACP)!!!!